Synthesis and reactivity of N-alkyl-2-oxoalkanesulfonamides

Article abstract of DOI:10.1016/S0040-4020(98)00093-3

A series of N-alkyl-2-oxoalkanesulfonamides have been synthesized by reacting silyl enol ethers with N-alkyl-sulfamoyl chlorides. Their reactivity towards electrophiles was investigated in order to explore the regio- and stereoselectivity of the process. 2-Oxoalkanesulfonamides were used to prepare 5-(methylsulfamoyl)-1,4-dihydropyridines derivatives.