The alkyne pathway to keramadine from the marine sponge Agelas sp.

DOI: 10.1016/S0040-4039(98)00341-4

Source and publish data:

Tetrahedron Letters p. 2541 - 2544 (1998)

Update date:2022-09-26

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Authors:

Lindel, Thomas

Hochguertel, Matthias

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Article abstract of DOI:10.1016/S0040-4039(98)00341-4

A novel synthesis of the pyrrole-imidazole alkaloid keramadine (1) from the marine sponge Agelas sp. is described. Regiocontrol is reached by the Pd- catalyzed alkynylation of 1-benzenesulfonyl-4-iodoimidazole, followed by N- methylation employing trimeth

Full text of DOI:10.1016/S0040-4039(98)00341-4

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