Bioorganic and Medicinal Chemistry Letters p. 2169 - 2272 (1998)
Update date:2022-08-03
Topics:
Dyatkin, Alexey B.
Brickwood, Janice R.
Proudfoot, John R.
The syntheses of 11-ethyl and 11-cyclopropyldipyrido[2,3-b:3',2'- f]azepines, analogs of the HIV-1 reverse transcriptase inhibitor nevirapine 1, are described. These compounds exhibit potency equivalent to nevirapine in the inhibition of wild-type and some mutant RT enzymes.
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