"Symmetry" in the synthesis of the A-ring of a vitamin D hybrid analogue with significant transactivation activity: A combinatorial sequence of regioselective propiolate-ene, catalytic enantioselective epoxidation and carbonyl-ene cyclization reactions

DOI: 10.1016/S0040-4039(98)00272-X

Source and publish data:

Tetrahedron Letters p. 3359 - 3362 (1998)

Update date:2022-08-03

Topics:

Authors:

Mikami, Koichi

Osawa, Ayako

Isaka, Akira

Sawa, Eiji

Shimizu, Masaki

Terada, Masahiro

Kubodera, Noboru

Nakagawa, Kimie

Tsugawa, Naoko

Okano, Toshio

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Article abstract of DOI:10.1016/S0040-4039(98)00272-X

The combination of the regioselective propiolate-ene reaction, catalytic enantioselective epoxidation and catalytic enantioselective carbonyl-ene cyclization completes the synthesis of the A ring of the hybrid 19-nor-22-oxa D₃ analogue (1), which shows the significant activity in transactivation.

Full text of DOI:10.1016/S0040-4039(98)00272-X

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