Synthesis and structure-activity relationship of substituted 1,2,3,4- tetrahydroisoquinolines as N-type calcium channel blockers

DOI: 10.1016/S0960-894X(98)00440-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2415 - 2418 (1998)

Update date:2022-08-05

Topics:

Authors:

Yuen, Po-Wai

Schelkun, Robert M.

Szoke, Balazs

Tarczy-Hornoch, Katalin

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00440-5

Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N- type VACC's have been identi

Full text of DOI:10.1016/S0960-894X(98)00440-5

Products guided by the article

Product name:2-[4,4-Bis-(4-fluorophenyl)butyl]-1,2,3,4-tetrahydroisoquinolin-5-ol

Cas No:208925-27-3

R&D Labs maybe for 208925-27-3

Neworld Chemical Co., Ltd Shanghai(expird)

Contact:+86-21-62202658

Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
JinTan Pingsheng Chemical Co.,Ltd

Contact:+86-519-82828200

Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Jiande City Silibase Silicone New Material Manufacture Co., Ltd.

Contact:15967177856

Address:Genglou Industrial Development Area
Fusilin chemical science & technology co., ltd.

Contact:532-80698166/86057573, +86-400-669-7885

Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong

Relevant to this article

Site-selective aliphatic C-H bromination using N -bromoamides and visible light

Doi:10.1021/ja508469u
(2014)
Complexes of cis-dioxomolybdenum(VI) with unsymmetrical tripodal NO₃-donor ligands: Synthesis, characterization and catalytic applications

Doi:10.1016/j.ica.2015.02.022
(2015)
Doi:10.1039/jr9520002987
(1952)
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

Doi:10.1016/S0960-894X(01)00029-4
(2001)
Synthesis and guanase inhibition studies of a novel ring-expanded purine analogue containing a 5:7-fused, planar, aromatic heterocyclic ring system

Doi:10.1016/S0960-894X(98)00672-6
(1998)
Doi:10.1039/j39680002959
(1968)

Article Doi