Synthesis and structure-activity relationship of substituted 1,2,3,4- tetrahydroisoquinolines as N-type calcium channel blockers

DOI: 10.1016/S0960-894X(98)00440-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2415 - 2418 (1998)

Update date:2022-08-05

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Authors:

Yuen, Po-Wai

Schelkun, Robert M.

Szoke, Balazs

Tarczy-Hornoch, Katalin

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Article abstract of DOI:10.1016/S0960-894X(98)00440-5

Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N- type VACC's have been identi

Full text of DOI:10.1016/S0960-894X(98)00440-5

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