Asymmetric direct α,β-functionalization of allenes via asymmetric carbopalladation

Article abstract of DOI:10.1246/cl.1998.397

Asymmetric direct α,β-functionalization of allenes with chiral phosphine ligands was successfully achieved with extremely high enantioselectivity via asymmetric carbopalladation to the racemic allenes. The same palladium-catalyzed alkylation of a chiral allene was executed with complete enantiospecificity. The stereochemistry of this reaction was determined and the mechanism of this asymmetric induction is proposed.