Design and synthesis of bio-isosteres of thymidine triphosphate

DOI: 10.1016/S0960-894X(98)00189-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1211 - 1214 (1998)

Update date:2022-07-30

Topics:

Authors:

Goldring, Alastair O.

Balzarini, Jan

Gilbert, Ian H.

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Article abstract of DOI:10.1016/S0960-894X(98)00189-9

This paper describes the design and synthesis of potential isosteres of triphosphates which should show enhanced metabolic stability and lipophilicity compared to triphosphates. The triphosphate isosteres were then linked to nucleosides and evaluated for their inhibitory activity against HIV infection.

Full text of DOI:10.1016/S0960-894X(98)00189-9

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