Phenylpyruvic acid derivatives as enzyme inhibitors: Therapeutic potential on macrophage migration inhibitory factor

Article abstract of DOI:10.1007/s00044-004-0102-y

Phenylpyruvic acid derivatives are obtained by hydrolysing aromatic Z/E azlactones. Keto tautomers interact with enzyme systems such as phenylalanine dehydrogenase or carboxypeptidase A whereas enol tautomers are potential inhibitors on the phenylpyruvate tautomerase activity catalysed by Macrophage Migration Inhibitory Factor (MIF). MIF being a key molecule in immune and inflammatory processes several structures with reasonable interaction with MIF and protocol for specific synthesis are presented. Birkhaeuser Boston 2004.

Full text of DOI:10.1007/s00044-004-0102-y

Med Chem Res 13:8/9 (2004) 565–577
௠ Birkha¨user Boston 2004

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