Stereoselective dihydroxylation of 2-alkyl- and 2,4-dialkyl-2-amido-3- cyclohexen-1-ones. Synthesis of enantiomerically related 2-alkyl- and 2,4- dialkyl-3-hydroxy-1-oxocyclohexan-2,4-carbolactones by complementary butyrolactonization reactions

Article abstract of DOI:10.1016/S0040-4039(98)01440-3

Stereoselective dihydroxylation of 2a-2f gives cis-diols 3a-3f, from which hydroxylactones 5a-5f are obtained by an acid-catalyzed process involving retro aldol-realdolization prior to transesterification.