Studies on 5-lipoxygenase inhibitors. I. Synthesis and 5-lipoxygenase- inhibitory activity of novel hydroxamic acid derivatives

DOI: 10.1248/cpb.46.966

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 966 - 972 (1998)

Update date:2022-08-05

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Authors:

Yatabe, Takumi

Kawai, Yoshio

Oku, Teruo

Tanaka, Hirokazu

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Article abstract of DOI:10.1248/cpb.46.966

A series of novel hydroxamates has been prepared and tested for inhibitory activity towards rat polymorphonuclear leukocyte (PMN) 5- lipoxygenase (5-LO) in vitro and towards neutrophil migration in the rat air pouch model of inflammation in vivo. Many 3,4

Full text of DOI:10.1248/cpb.46.966

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