Tetrahedron Letters p. 4591 - 4594 (1998)
Update date:2022-09-26
Topics:
Bleicher, Konrad H.
Wareing, James R.
A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described. Improved acid stability compared to the common trityl linker is demonstrated by a quantitative method for analysis of loading. This new linker is used for the synthesis of a peptide alcohol in the 'inverse' direction via reduction of the corresponding N linked peptide methyl ester. Several other nucleophiles are immobilized and further modified. TFA treatment releases the corresponding products in high purity.
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Doi:10.1055/s-0040-1707236
(2020)Doi:10.1021/ja010498k
(2001)Doi:10.1016/S0040-4020(98)01174-0
(1999)Doi:10.1021/jo001190z
(2001)Doi:10.1021/jm980101w
(1998)Doi:10.1016/S0040-4039(98)01174-5
(1998)
