Tetrahedron Letters p. 4591 - 4594 (1998)
Update date:2022-09-26
Topics:
Bleicher, Konrad H.
Wareing, James R.
A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described. Improved acid stability compared to the common trityl linker is demonstrated by a quantitative method for analysis of loading. This new linker is used for the synthesis of a peptide alcohol in the 'inverse' direction via reduction of the corresponding N linked peptide methyl ester. Several other nucleophiles are immobilized and further modified. TFA treatment releases the corresponding products in high purity.
View MoreContact:+86-021-58123769
Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
Shanghai Massive Chemical Technology Co., Ltd.
website:http://www.massivechem.com/
Contact:+86 21 34943721
Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Chengda Pharmaceuticals Co., Ltd.
Contact:+86-573-84601188
Address:hengshan Road 5# in Jiashan, zhejiang
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.
Contact:+86-512-6585 6968
Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Jinan Hongfangde Pharmatech Co.LTD
Contact:0531-88870908
Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Doi:10.1055/s-0040-1707236
(2020)Doi:10.1021/ja010498k
(2001)Doi:10.1016/S0040-4020(98)01174-0
(1999)Doi:10.1021/jo001190z
(2001)Doi:10.1021/jm980101w
(1998)Doi:10.1016/S0040-4039(98)01174-5
(1998)
