PhFl acetic acid: A new linker for solid phase organic synthesis

Article abstract of DOI:10.1016/S0040-4039(98)00846-6

A 9-phenylfluoren-9-yl based linker for the immobilization of nitrogen and oxygen nucleophiles is described. Improved acid stability compared to the common trityl linker is demonstrated by a quantitative method for analysis of loading. This new linker is used for the synthesis of a peptide alcohol in the 'inverse' direction via reduction of the corresponding N linked peptide methyl ester. Several other nucleophiles are immobilized and further modified. TFA treatment releases the corresponding products in high purity.