Asymmetric synthesis of the mC7N core of the manumycin family: Preparation of (+)-MT 35214 and a formal total synthesis of (-)-alisamycin

Article abstract of DOI:10.1016/S0040-4039(98)01047-8

An asymmetric approach to the mC₇N epoxyquinone central unit of the manumycin antibiotics is described based on the enantioselective (89% ee) chiral phase transfer epoxidation of a substituted cyclohexenone. The chiral epoxide is employed in the trust syntheses of the title compounds in enantiomerically pure form.