Synthesis and structure-activity relationships of 2-pyridones: II. 8- (fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents

Article abstract of DOI:10.1016/S0960-894X(98)00355-2

The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.