Synthesis of a C11 spiropiperidino derivative of 8-chloro-6,11- dihydro 5H-benzo[5,6]cyclohepta[1,2-b]pyridine

DOI: 10.1016/S0040-4039(98)01714-6

Source and publish data:

Tetrahedron Letters p. 7661 - 7664 (1998)

Update date:2022-07-29

Topics:

Authors:

Afonso, Adriano

Kelly Kelly

Puar, Mohindar S.

McCombie, Stuart

McPhail, Andrew T.

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Article abstract of DOI:10.1016/S0040-4039(98)01714-6

A method using N-tosyl aziridine for the synthesis of a spiropiperidine 2 (R=H) is described. Cleavage of the N-tosyl group of the intermediate 8 to form the spiropiperidinone 9 was found to proceed in high yield with conc. sulfuric acid. Acylated derivat

Full text of DOI:10.1016/S0040-4039(98)01714-6

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