Synthetic Communications p. 4419 - 4429 (1998)
Update date:2022-08-05
Topics:
Lila, Christine
Gloanec, Philippe
Cadet, Laurence
Herve, Yolande
Fournier, Jean
Leborgne, Fabrice
Verbeuren, Tony J.
De Nanteuil, Guillaume
To allow the preparation of melagatran on a multigram scale, we have investigated several approaches for the synthesis of the key intermediate 4- aminomethylbenzamidine. The only industrially suitable pathway relies on the preparation of an N-hydroxyimino
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(2004)Doi:10.1021/ol006255z
(2000)Doi:10.1139/v74-442
(1974)Doi:10.1016/s0020-1693(98)00162-5
(1998)Doi:10.1039/a806769d
(1998)Doi:10.1021/jm980328r
(1998)