A stereoselective α-fucosylation reaction using 1-hydroxy 2,3,4-trio- benzyl-L-fucose donor for the practical synthesis of selectin blocker

Article abstract of DOI:10.1016/S0960-894X(98)00516-2

A 1-hydroxy 2,3,4-tri-O-benzyl-L-fucose donor affords a high stereoselectivity of glycosylation in the presence of TMSOTf and is a very useful substrate for the preparation of an α-L-fucosyl dipeptide in a stereoselective manner. The donor will be a key component in the preparation of an attractively biological selectin blocker 1.