Antimitotic agents interacting with tubulin: Synthesis and structure- activity relationships of novel ortho bridged biphenyis of the rhazinilam type

Article abstract of DOI:10.1016/S0040-4020(98)00903-X

Several new ortho bridged biphenyls mimicking the structure of (-)- rhazinilam were synthesized and evaluated as cytotoxic compounds and as inhibitors of microtubules disassembly. These included azadibenzo[a,c]cyclononene derivatives having an ester, urea