Antimitotic agents interacting with tubulin: Synthesis and structure- activity relationships of novel ortho bridged biphenyis of the rhazinilam type

DOI: 10.1016/S0040-4020(98)00903-X

Source and publish data:

Tetrahedron p. 14737 - 14756 (1998)

Update date:2022-08-02

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Authors:

Pascal, Cecile

Dubois, Joelle

Guenard, Daniel

Tchertanov, Luba

Thoret, Sylviane

Gueritte, Francoise

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Article abstract of DOI:10.1016/S0040-4020(98)00903-X

Several new ortho bridged biphenyls mimicking the structure of (-)- rhazinilam were synthesized and evaluated as cytotoxic compounds and as inhibitors of microtubules disassembly. These included azadibenzo[a,c]cyclononene derivatives having an ester, urea

Full text of DOI:10.1016/S0040-4020(98)00903-X

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