Synthesis and evaluation of novel coumarin-based esterase-sensitive cyclic prodrugs of peptidomimetic RGD analogs with improved membrane permeability

DOI: 10.1248/cpb.47.90

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Chemical and Pharmaceutical Bulletin p. 90 - 95 (1999)

Update date:2022-08-04

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Authors:

Wang, Binghe

Wang, Wei

Camenisch, Gian P.

Elmo, Jennifer

Zhang, Huijuan

Borchardt, Ronald T.

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Article abstract of DOI:10.1248/cpb.47.90

Earlier, we reported the development of a coumarin-based prodrug system that could be used for the preparation of cyclic prodrugs of opioid peptides. These cyclic prodrugs exhibited excellent membrane permeability characteristics. Therefore, it was of int

Full text of DOI:10.1248/cpb.47.90

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