A novel asymmetric synthesis of 2,5-dialkylpyrrolidines

Article abstract of DOI:10.1016/S0040-4039(99)00058-1

ZnCl₂-promoted cyclization of enamino ester 8 furnished a 1.5:1 mixture of pyrrolidines 9 and 10. NaBH₄-reduction of this mixture gave cis and trans-2,5-dialkylpyrrolidines 12 and 13 in the ratio 2:1. The latter derivative was obtain