Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library

DOI: 10.1248/cpb.47.194

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Chemical and Pharmaceutical Bulletin p. 194 - 198 (1999)

Update date:2022-08-02

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Authors:

Vendeville, Sandrine

Buisine, Eric

Williard, Xavier

Schrevel, Joseph

Grellier, Philippe

Santana, Jaime

Sergheraert, Christian

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Article abstract of DOI:10.1248/cpb.47.194

Two orthogonal peptide combinatorial libraries were screened to discover inhibitors of Tc80 protease, a novel target from Trypanosoma cruzi involved in host cell invasion. These libraries were composed of 15625 structurally diversified tripeptides, partit

Full text of DOI:10.1248/cpb.47.194

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