Synthesis and biodistribution of technetiuim-99m-labelled N-(diethylaminoethyl)benzamide via a bis(dithiocarbamate) nitridotechnetium(V) complex.

Article abstract of DOI:10.1002/(SICI)1099-1344(199904)42:4<325::AID-JLCR193>3.0.CO;2-J

N-(2-diethylaminoethyl)-4-iodobenzamide has been reported to be an excellent agent for malignant melanoma diagnosis by SPECT. To obtain a ^99mTc analogue, we synthesized a sodium {2-[4-(N-diethylaminoethylcarbamoyl)phenyl]ethyl}-N-methyldithiocarbamate ligand in 7 steps from methyl 4-(bromomethyl)benzoate. The corresponding nitridotechnetium complex formed by a ligand exchange method was purified and its biodistribution in mice bearing the B16 murine melanoma was determined.