Efficient total synthesis of pentosidine, an advanced glycation endproduct

Article abstract of DOI:10.1016/S0040-4039(99)00204-X

The efficient total synthesis of pentosidine (1), an advanced glycation endproduct, was achieved using the asymmetric alkylation of a chiral schiff base (2), the intramolecular guanylation with mercury (II) chloride, and the quaternization accompanied by removal of the trityl group as key steps.