Bioorganic and Medicinal Chemistry Letters p. 895 - 900 (1999)
Update date:2022-08-05
Topics:
Reiner, John E.
Lim-Wilby, Margeurita S.
Brunck, Terence K.
Ha-Uong, Theresa
Goldman, Erick A.
Abelman, Matthew A.
Nutt, Ruth F.
Semple, J. Edward
Tamura, Susan Y.
A novel scaffold for P4-P2 dipeptide mimics containing a rigid pyridone spacer was designed based on a virtual library strategy. Several selected nonpeptidic 4-aralkyl or 4-alkylpyridones incorporating a P1- argininal sequence were prepared. The modeling studies, synthesis and biological activities of these unique pyridone derivatives are reported herein.
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