Organic Letters
Letter
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α-acetoxy ketone 31 (eq 2). Ketone 31 resembles JTP-4819, a
prolyl endopeptidase inhibitor and cognition enhancer.49
Further investigation of copper-catalyzed allene difunctionaliza-
tions and application of products derived thereof are merited.
ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
Experimental procedures, characterization of new com-
pounds, and copies of NMR spectra (PDF)
(38) Zacharia, J. T.; Tanaka, T.; Hayashi, M. J. Org. Chem. 2010, 75,
7514.
AUTHOR INFORMATION
Corresponding Author
■
(39) Poladura, B.; Martinez-Castaneda, A.; Rodriguez-Solla, H.;
Llavona, R.; Concellon, C.; del Amo, V. Org. Lett. 2013, 15, 2810.
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Notes
The authors declare no competing financial interest.
(42) Melis, K.; Opstal, T.; Verpoort, F. Eur. J. Org. Chem. 2002, 2002,
3779.
ACKNOWLEDGMENTS
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(43) Nishiumi, M.; Miura, H.; Wada, K.; Hosokawa, S.; Inoue, M. ACS
Catal. 2012, 2, 1753.
(44) Chary, B. C.; Kim, S. J. Org. Chem. 2010, 75, 7928.
(45) Doucet, H.; Martin-Vaca, B.; Bruneau, C.; Dixneuf, P. H. J. Org.
Chem. 1995, 60, 7247.
(46) Paderes, M. C.; Belding, L.; Fanovic, B.; Dudding, T.; Keister, J.
B.; Chemler, S. R. Chem. - Eur. J. 2012, 18, 1711.
(47) King, A. E.; Brunold, T. C.; Stahl, S. S. J. Am. Chem. Soc. 2009, 131,
5044.
(48) Shade, R. E.; Hyde, A. M.; Olsen, J.-C.; Merlic, C. A. J. Am. Chem.
Soc. 2010, 132, 1202.
The financial support of the National Institutes of Health
(NIGMS RO1 078383) is gratefully acknowledged. The
Egyptian Government is gratefully acknowledged for the
graduate school fellowship to Z.M.K.
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