Synthesis of atropisomeric diamides with remotely related stereogenic axes by stereoselective additions to imines

Article abstract of DOI:10.1016/S0040-4039(99)00520-1

Atroposelective addition of axially chiral laterally lithiated 2-alkyl- 1-naphthamides to 6-substituted 2-(N-methylformimino)benzamides leads, after equilibration of the new stereogenic axis to its more stable conformation, to single atropisomeric diaster