(2S,3S)- and (2R,3S)-2-[2-(benzyloxy)ethyl]-3-(6-chloro-9H-purin-9-yl)oxolane

Article abstract of DOI:10.1107/S0108270199002784

The title diastereomeric compounds, C₁₈H₁₉ClN₄O₂, are the products formed when the (2S,3S)- and (2R,3S)-3-(5-amino-6-chloropyrimidinyl)amino-2-(2-benzyloxy)ethyl-oxolanes are treated with triethyl orthoformate in the presence of 4-toluenesulfonic acid. The crystal structure determination unambiguously shows the cis and trans orientations, respectively, of the 2-benzyloxyethyl and the 6-chloropurinyl substituents of the oxolanyl ring.