Synthesis and spectral properties of 5-methylthio-4H-1-(p-substituted- phenyl)-3a-(p-substituted-phenyl)-9-([(m-; and p-substituted)-phenoxyl-3a,4- dihydro[1,2,4]oxadiazolo[4,5-a][1,5]benzodiazepines

Article abstract of DOI:10.1002/jhet.5570360224

The preparation of eight novel substituted [1,2,4]oxadiazolo[4,5- a][1,5]benzodiazepines which have potentially useful pharmacological properties; by 1,3-cycloaddition of benzonitrile oxides, generated in situ from benzohydroxamoyl chloride and triethylamine, to 1,5-benzodiazepine derivatives is described. The structure of all products was corroborated by ir, ¹H-nmr, ¹³C-nmr and ms.