Tetrahedron Letters p. 5601 - 5604 (1999)
Update date:2022-09-26
Topics:
Slade, Christopher J.
Pringle, Carol A.
Sumner, Ian G.
The carboxylic acid functionality can be protected as the 1,2,3,4- tetrahydro-1-naphthyl ester, which can be selectively cleaved in the presence of aryl and alkyl esters using chlorotrimethylsilane and sodium iodide in acetonitrile. This protecting group allows room temperature deprotection under essentially neutral conditions throughout the cleavage reaction.
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(1999)Doi:10.1111/1468-0289.00176
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(2017)
