Enantioselective syntheses of α-substituted glutamic acids and α,γ-disubstituted glutamic acids by an asymmetric Strecker reaction

Article abstract of DOI:10.1016/S0040-4039(99)01121-1

The Strecker reaction of the product from the treatment of the sodium salt of γ-keto acids with (S)-phenylglycinol followed by heating the products to 200 °C gives the bicyclic lactones 9 and 10. Alkylation of 9 provides 11 and 12. Both 9b and 11a are con