A biotin phosphoramidite reagent for the automated synthesis of 5'- biotinylated oligonucleotides

Article abstract of DOI:10.1080/07328319908044672

A bis(DMTr)biotin phosphoramidite containing serine and 6-aminohexanol moieties was prepared by a multiple-step reaction, and used successfully in the solid phase synthesis of 5'-biotinylated oligonucleotides.

Full text of DOI:10.1080/07328319908044672

This article was downloaded by: [Unam - Centro De Nano Ciencias]
On: 25 December 2014, At: 21:55
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
A Biotin Phosphoramidite Reagent
for the Automated Synthesis of 5′-
Biotinylated Oligonucleotides
Zhengyun Zhao a & John Ackroyd a
a Cruachem Limited, Todd Campus, West of Scotland Science Park ,
Acre Road, Glasgow, G20 OUA
Published online: 04 Oct 2006.
To cite this article: Zhengyun Zhao & John Ackroyd (1999) A Biotin Phosphoramidite Reagent for
the Automated Synthesis of 5′-Biotinylated Oligonucleotides, Nucleosides and Nucleotides, 18:6-7,
1231-1234, DOI: 10.1080/07328319908044672
To link to this article: http://dx.doi.org/10.1080/07328319908044672
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or
howsoever caused arising directly or indirectly in connection with, in relation to or arising
out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &
Conditions of access and use can be found at http://www.tandfonline.com/page/terms-
and-conditions