Activation of the reverse-cope elimination by allylic oxygen functions: Syntheses of (-)-hygroline and (+)-pseudohygroline

Article abstract of DOI:10.1016/S0040-4039(99)01131-4

Reverse-Cope cyclisations of N-(4-alkenyl)hydroxylamines 8 are accelerated by the presence of the allylic oxygen function; this has been applied to a brief synthesis of the alkaloids (-)-hygroline 6 and (+)- pseudohygroline 7.