Aryl H-phosphonates. 10. Synthesis of nucleoside phosphoramidate and nucleoside phosphoramidothioate analogues via H-phosphonamidate intermediates

Article abstract of DOI:10.1016/S0040-4020(99)00656-0

Synthesis of a new type of dinucleoside monophosphate analogue with the 3'-5' H-phosphonamidate internucleoside linkage, namely thymidin-3'-yl N(thymidin-5'-yl)-H-phosphonamidate 4, was achieved via the reaction of a suitably protected nucleoside aryl H-p