Bioorganic and Medicinal Chemistry Letters p. 3059 - 3062 (2002)
Update date:2022-08-04
Topics:
Firooznia, Fariborz
Gude, Candido
Chan, Kenneth
Tan, Jenny
Fink, Cynthia A.
Savage, Paula
Beil, Michael E.
Bruseo, Charles W.
Trapani, Angelo J.
Jeng, Arco Y.
Directed screening of metalloprotease inhibitors identified CGS 30084 (1) as a potent inhibitor of endothelin-converting enzyme-1 (ECE-1) in vitro (IC50=77 nM). Herein we report the syntheses and biological activities of analogues containing modified biphenyl moieties, bearing heterocyclic proximal rings. Compound 20, the thioacetate ethyl ester prodrug derivative of compound 19a, was found to be an orally active and potent inhibitor of ECE-1 activity in rats.
View MoreZibo Jujin Chemical Industry Co., Ltd.(Dongming Jujin Chemical Industry Co., Ltd. )
Contact:+86-533-2975022
Address:No.99 Shanquan Road, Zhangdian District
SHAANXI FUJIE PHARMACEUTICAL CO.,LTD
website:http://www.fujiepharm.com
Contact:+86-29-63650906
Address:Yuanqu Yi Road, Qinghe Food Industrial Park, Sanyuan County, Shaanxi Province, China
Contact:86-898-65311214
Address:Room 102, BLDG. 68 Jiangnan City, No. 66 Heping Road,Haikou, Hainan, China
zhejiang huangyan wanfeng pharm chem co.ltd
Contact:+86-576- 84160728
Address:No. 5 Dazha Road, Economic,Development Zone(JiangKou), Zhejiang, China
Suzhou BEC Fine Chemicals Co., Ltd.
website:http://www.bek.com.cn
Contact:0512-68095917 18913193865
Address:6, Jin Shan Road, Suzhou New District, 215011 China Suzhou Nations Pharmaceutical Innovation Center Inside
Doi:10.1016/S0040-4020(99)00644-4
(1999)Doi:10.1039/c9gc01195a
(2019)Doi:10.1016/S0040-4020(02)00045-5
(2002)Doi:10.1002/jhet.2620
(2017)Doi:10.1039/j39700000049
(1970)Doi:10.1021/ol990281j
(1999)