Syntheses of inhibitors for the enzyme thymidine 5'-diphosphate-glucose-4,6-dehydratase (EC 4.2.1.46)

Article abstract of DOI:10.1016/S0008-6215(99)00074-9

Inhibitors of the enzyme thymidine 5'-diphosphate-glucose-4,6-dehydratase (EC 4.2.1.46) were synthesised starting from thymidine, 2-deoxy-uridine and -cytidine. The diphosphate moieties have either been replaced by methylene diphosphonate or phosphoryl hy