The synthesis of a new class of oxytocin antagonists

Article abstract of DOI:10.1016/S0960-894X(99)00478-3

The synthesis of a new class of oxytocin antagonists, with significantly modified C-terminal part, is described. The chemistry of the Mitsunobu reaction was applied to obtain the key derivatives. In spite of the extensive modifications of previously described compound F792, the peptides retain biological activity as oxytocin antagonists.