Bioorganic and Medicinal Chemistry Letters p. 2801 - 2804 (1999)
Update date:2022-07-29
Topics:
Wisniewski, Kazimierz
Trojnar, Jerzy
Riviere, Pierre
Haigh, Robert
Yea, Chris
Ashworth, Doreen
Melin, Per
Nilsson, Anders
The synthesis of a new class of oxytocin antagonists, with significantly modified C-terminal part, is described. The chemistry of the Mitsunobu reaction was applied to obtain the key derivatives. In spite of the extensive modifications of previously described compound F792, the peptides retain biological activity as oxytocin antagonists.
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