Tetrahedron Letters p. 8759 - 8762 (1999)
Update date:2022-07-30
Topics:
You, Fengxiang
Twieg, Robert J.
The compound 4-hydroxypyridine is reacted with aromatic substrates that have a leaving group (usually halogen) and that is activated by an electron- withdrawing group or a heterocycle. Only N-aryl-4(1H)-pyridones are produced in this efficient aromatic nucleophilic substitution reaction. Some mechanistic aspects of the reaction have also been examined.
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