Bioorganic and Medicinal Chemistry Letters p. 3159 - 3164 (1999)
Update date:2022-09-26
Topics:
De Jonghe, Steven
Van Overmeire, Ilse
Gunst, Johan
De Bruyn, Andre
Hendrix, Chris
Van Calenbergh, Serge
Busson, Roger
De Keukeleire, Denis
Philippe, Jan
Herdewijn, Piet
Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.
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