Synthesis of a complete series of C-4 fluorinated Phe-Gly mimetics

DOI: 10.1016/S0040-4020(99)00865-0

Source and publish data:

Tetrahedron p. 13819 - 13830 (1999)

Update date:2022-08-02

Topics: Synthesis C-4 fluorinated

Authors:

Berts, Wei

Luthman, Kristina

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Article abstract of DOI:10.1016/S0040-4020(99)00865-0

The complete series of Boc-protected allylic mono- and difluorinated Phe-Gly methyl ester derivatives has been synthesized using facile methods. Diastereomeric allylic alcohol derivatives were used as key intermediates, cis- And trans-aziridine derivative

Full text of DOI:10.1016/S0040-4020(99)00865-0

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Product name:(S)-5-[(tert-butoxycarbonyl)amino]-1-hydroxy-6-phenyl-(E)-2-hexen-4-one

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