Synthesis of [carbonyl-14C]-4-benzoylbenzoic acid, a photolabelling reagent

Article abstract of DOI:10.1002/(SICI)1099-1344(199912)42:12<1175::AID-JLCR272>3.0.CO;2-5

[carbonyl-¹⁴C]-4-Benzoylbenzoic acid, a photolabelling reagent, was synthesised with high specific activity in 57% radioactive yield from [carboxyl-¹⁴C]-benzoic acid. Radioactive synthesis allowed elucidation of the mechanism of a previous unlabelled synthesis using benzoic acid, methyl ester. An improvement in the experimental conditions led to a new synthesis of radioactive benzoylbenzoic derivatives with good yield.