Preparation and Evaluation of Electrophilic Derivatives of Phenylbutazone as Inhibitors of Prostaglandin-H Synthase

DOI: 10.1021/jm00386a020

Source and publish data:

Journal of Medicinal Chemistry p. 563 - 567 (1987)

Update date:2022-08-05

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Authors:

Vennerstrom, Jonathan L.

Holmes, Thomas J.

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Article abstract of DOI:10.1021/jm00386a020

The chemical syntheses and biological evaluation of several potential irreversible inhibitors for prostaglandin (PGH) synthase are described.These inhibitors were modeled after the nonsteroidal antiinflammatory (NSAI) drug phenylbutazone(4-n-butyl-1,2-dip

Full text of DOI:10.1021/jm00386a020

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