Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety

Article abstract of DOI:10.1016/S0960-894X(98)00724-0

4-Hydroxymethyl-5a-methyl-1,3,4,5,5aβ,6,7,8,9,9aα-decahydro-2H- benz[d]azepin-2-ones (4-12), which were designed to mimic the biologically active conformation of teleocidins and benzolactams, were synthesized and evaluated for the ability to compete with