A new synthetic entry to 3-carboxamido-4-carboxylic acid derivatives of isoxazole and pyrazole

DOI: 10.1002/jhet.5570370129

Source and publish data:

Journal of Heterocyclic Chemistry p. 175 - 180 (2000)

Update date:2022-07-29

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Authors:

Vicentini, Chiara B.

Mazzanti, Manuela

Morelli, Carlo F.

Manfrini, Maurizio

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Article abstract of DOI:10.1002/jhet.5570370129

Ethyl 2-amino-3-methoxycarbonyl-4-oxo-2-pentenoate (3) reacts with hydroxylamine or hydrazines to give isoxazole and pyrazole ortho-dicarboxylic acid esters 4 and 5, respectively. Partial hydrolysis of diesters 4 and 5 afforded the corresponding dicarboxy

Full text of DOI:10.1002/jhet.5570370129

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