Synthesis of a potent aminocyclitol α-mannosidase inhibitor, 1L-(1,2,3,5/4)-5-amino-4-O-methyl-1,2,3,4-cyclopentanetetrol

Article abstract of DOI:10.1016/S0960-894X(00)00162-1

Demethylthio-, de-S-methyl-, and ethylthio-derivatives of the α-mannosidase inhibitor, mannostatin A, have been synthesized and evaluated for their inhibition of Jack bean α-mannosidase in order to elucidate the roles of the methylthio group. All derivati