Bioorganic and Medicinal Chemistry Letters p. 1927 - 1929 (2000)
Update date:2022-09-26
Topics:
Baldwin, Jack E.
Pritchard, Gareth J.
Williamson, Douglas S.
The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools for neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel fashion via mesylate displacement by a number of aromatic and heteroaromatic thiolates upon (2S,3S,4R)-1-benzoyl-3-tert-butoxycarbonylmethyl-4-methanesulfony loxy pyrrolidine-2-carboxylic acid methyl ester 8, which is obtainable in eight steps from trans-4-hydroxy-L-proline 5. (C) 2000 Elsevier Science Ltd.
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