New strategies for the chemical synthesis of biologically important nucleic acid derivatives

Article abstract of DOI:10.1080/07328319808004744

This paper describes general methods for the synthesis of N- phosphorylated ribonucleosides and oligonucleotides containing a 2'-O- phosphorylated or 2'-O-thiophosphorylated ribonucleoside. The NMR-based conformational analysis and computational molecular dynamics simulation of the 2'-O-phosphorylated ribonucleoside residue in such modified oligonucleotides suggested that the ribose residue existed preferentially in a C2'-endo conformation. It was also found that simple heating of 2'-O- phosphorylated oligonucleotides resulted in rapid dethiophosphorylation.

Full text of DOI:10.1080/07328319808004744

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Nucleosides and Nucleotides
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New Strategies for the Chemical
Synthesis of Biologically Important
Nucleic Acid Derivatives
Mitsuo. Sekine a , Hiroyuki. Tsuruoka a , Koh-ichiro. Shohda a
Tomohisa. Moriguchi a & Tomohisa. Wada a
,
a Department of Life Science , Tokyo Institute of Technology
Nagatsuta , Midoriku, Yokohama, 226, Japan
Published online: 22 Aug 2006.
To cite this article: Mitsuo. Sekine , Hiroyuki. Tsuruoka , Koh-ichiro. Shohda , Tomohisa. Moriguchi &
Tomohisa. Wada (1998) New Strategies for the Chemical Synthesis of Biologically Important Nucleic
Acid Derivatives, Nucleosides and Nucleotides, 17:9-11, 2033-2043, DOI: 10.1080/07328319808004744
To link to this article: http://dx.doi.org/10.1080/07328319808004744
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