Nucleosides and Nucleotides p. 2033 - 2043 (1998)
Update date:2022-08-02
Topics:
Sekine, Mitsuo
Tsuruoka, Hiroyuki
Shohda, Koh-Ichiro
Moriguchi, Tomohisa
Wada, Takeshi
This paper describes general methods for the synthesis of N- phosphorylated ribonucleosides and oligonucleotides containing a 2'-O- phosphorylated or 2'-O-thiophosphorylated ribonucleoside. The NMR-based conformational analysis and computational molecular dynamics simulation of the 2'-O-phosphorylated ribonucleoside residue in such modified oligonucleotides suggested that the ribose residue existed preferentially in a C2'-endo conformation. It was also found that simple heating of 2'-O- phosphorylated oligonucleotides resulted in rapid dethiophosphorylation.
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