A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair

DOI: 10.1016/S0960-894X(98)00051-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 453 - 458 (1998)

Update date:2022-08-04

Topics:

Authors:

Guay, Daniel

Gauthier

Dufresne

Jones Jones

McAuliffe

McFarlane

Metters Metters

Prasit Prasit

Rochette

Roy Roy

Sawyer Sawyer

Zamboni Zamboni

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Article abstract of DOI:10.1016/S0960-894X(98)00051-1

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singular) is described. This work has led to the identification of a number of potent and orally active cysLT₁ receptor (LTD₄ receptor) antagonists including 2ab (L-733,321) as an optimized candidate.

Full text of DOI:10.1016/S0960-894X(98)00051-1

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