A potent, long-acting, orally active (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: A novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors

DOI: 10.1021/jm0003135

Source and publish data:

Journal of Medicinal Chemistry p. 5017 - 5029 (2000)

Update date:2022-09-26

Topics:

Authors:

Mitsuya Mitsuya

Kobayashi

Kawakami

Satoh Satoh

Ogino Ogino

Kakikawa

Ohtake Ohtake

Kimura Kimura

Hirose Hirose

Sato Sato

Numazawa

Hasegawa

Noguchi Noguchi

Mase Mase

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Article abstract of DOI:10.1021/jm0003135

A novel series of (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamides was designed and synthesized based on the structure and biological profiles of an active metabolite 2 of our prototype muscarinic M₃ receptor selective antagon

Full text of DOI:10.1021/jm0003135

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