cis- and trans-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinolines

Article abstract of DOI:10.1002/jps.2600740619

cis- and trans-4-n-Propyloctahydrobenzo(f)quinolines 4a,b were prepared for further assessment of dopaminergic effects of nonoxygenated dopamine congeners. The trans isomer 4b exhibited marked dopamine-like effects in the cat cardioaccelerator nerve assay and in a rat rotation model. Compound 4b produced dose-related lowering of blood pressure in the cat. The cis isomer 4a was inactive in these assays. Both compounds were inactive in a dopamine binding assay, but both appeared active in a spiroperidol binding assay. Both compounds are active α₁ and α₂-adrenoceptor antagonists. Compound 4b provides evidence that α₂-adrenoceptors and dopamine receptors are different entities, since this compound is an α₂ antagonist and a dopamine receptor agonist at presynaptic sites.