Nickel-Catalyzed β-Regioselective Amination/Cyclization of Ynamide-Nitriles with Amines: Synthesis of Functionalized 3-Aminoindoles and 4-Aminoisoquinolines

DOI: 10.1021/acs.orglett.0c04278

Source and publish data:

Organic Letters p. 1296 - 1301 (2021)

Update date:2022-09-26

Topics:

Authors:

Hu, Xiaoping

Xie, Xin

Gan, Yi Gan, Yi

Wang, Gaonan

Liu, Yuanhong

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Article abstract of DOI:10.1021/acs.orglett.0c04278

A highly regioselective nickel/Lewis acid catalyzed amination/cyclization of ynamide-nitriles with amines involving β-addition has been developed. The reaction offers an attractive and efficient route for the synthesis of 3-aminoindoles and 4-aminoisoquinoline derivatives. The Ts-group on the ynamide acts as a directing group to produce the alkenyl nickel species with high regioselectivity.

Full text of DOI:10.1021/acs.orglett.0c04278

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