Synthesis of high-specific-radioactivity 4- and 6-[18F]fluorometaraminol- PET tracers for the adrenergic nervous system of the heart

DOI: 10.1016/S0968-0896(00)00286-8

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Bioorganic and Medicinal Chemistry p. 677 - 694 (2001)

Update date:2022-07-29

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Authors:

Langer, Oliver

Dollé, Frédéric

Valette, Héric

Halldin, Christer

Vaufrey, Fran?oise

Fuseau, Chantal

Coulon, Christine

Ottaviani, Michéle

N?gren, Kjell

Bottlaender, Michel

Maziére, Bernard

Crouzel, Christian

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Article abstract of DOI:10.1016/S0968-0896(00)00286-8

Fluorine-18 (t₁₂:109.8min)-labeled analogues of metaraminol, 4-[¹⁸F]FMR ((1R,2S)-2-amino-1-(4-[¹⁸F]fluoro-3-hydroxy phenyl)-1-propanol) and 6-[¹⁸F]FMR ((1R,2S)-2-amino-1-(2-[¹⁸F]fluoro-5-hydroxyphenyl)-1-propanol), were synthesized as new positron-emission-tomography (PET) tracers for mapping cardiac adrenergic nerve terminals. Copyright

Full text of DOI:10.1016/S0968-0896(00)00286-8

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